TO ESTIMATE AND CORRELATE LEVELS OF GHRELIN AND LEPTIN IN GINGIVAL CREVICULAR FLUID OF HEALTH, CHRONIC GENERALIZED PERIODONTITIS OF PATIENTS WITH AND WITHOUT OBESITY – A CLINICO-BIOCHEMICAL STUDY ?.

Not Applicable

Conditions: Health Condition 1: Z68- Body mass index [BMI]

Registration Number: CTRI/2024/01/061099

Lead Sponsor: DR. G.NAGATULSI

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

· Subjects of either sex, between the ages of 20 years and 60 years.

· Presence of at least 20 natural teeth.

· Individuals with healthy periodontium.

Subjects with normal lipid profile having BMI values as given by Asian Specific Perspective Obesity-WHO 2000.

1.BMI in range of 18.5-22.9 kg/m2 in non-obese

Waist circumference (WC)

men : WC= 90cm

women : WC=80cm

2. BMI in range of 25-29.9 kg/m2 in obese

men : WC =90cm

women : WC =80cm

· Patients with diagnosis of generalized stage III grade B periodontitis.

(Periodontal health, gingivitis and periodontitis definition will be based on the classification of periodontal and peri-implant diseases and conditions as proposed in 2017 World Workshop).

Exclusion Criteria

· Individuals who have received periodontal therapy in the last 6 months.

· Individuals with systemic diseases other than type 2 diabetes mellitus (HbA1c < 7.0) · Individuals who have history of antimicrobial and anti-inflammatory therapy in the past 6 months · Pregnant/lactating and postmenopausal women.

· Smokers.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
· To estimate the levels of Ghrelin and leptin in GCF of subjects in health and chronic periodontitis with or without obesity at baseline. <br/ ><br>· To correlate the levels of Ghrelin and leptin in GCF of subjects in health and chronic periodontitis with or without obesity at baseline. <br/ ><br>· To explore the possibility of using Ghrelin and leptin as a marker for inflammation in generalized stage III grade B periodontitis and relate them with clinical parameters at baseline. <br/ ><br>Timepoint: · To estimate the levels of Ghrelin and leptin in GCF of subjects in health and chronic periodontitis with or without obesity AT THE BASELINE <br/ ><br>· To correlate the levels of Ghrelin and leptin in GCF of subjects in health and chronic periodontitis with or without obesity AT BASE LINE <br/ ><br>· To explore the possibility of using Ghrelin and leptin as a marker for inflammation in generalized stage III grade B periodontitis and relate them with clinical parameters AT BASE LINE. <br/ ><br>

Secondary Outcome Measures