Biological Markers to Identify Early Sepsis and Acute Lung Injury

Completed

• Conditions: Acute Lung Injury; Sepsis

• Registration Number: NCT00825357
• Lead Sponsor: Chimei Medical Center

Brief Summary

There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St. Michael's Hospital, Toronto, we have initiated a pilot study looking for biological markers to detect severe sepsis and ARDS. We have found that human neutrophils peptides (a-defensins), certain coagulation variables and cytokine levels are very sensitive markers to differentiate severe sepsis, ARDS from cardiovascular diseases in ICU patients. These findings may provide valuable information for therapeutic guideline in clinical practice. The present study will focus on testing 'biological markers' to identify patients with sepsis and acute lung injury. We will examine the roles of three components of markers including inflammation, neutrophil activation and coagulation. We are hoping that this proposed translational research will help develop novel therapeutic strategy in sepsis and acute lung injury patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09
• Study First Submitted: 2009-01-15
• Study First Submitted QC: 2009-01-20
• Study First Posted: 2009-01-21
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-26
• Last Update Posted: 2016-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Meet diagnostic criteria of ≧2 SIRS or acute lung injury.
• Get agreement of patient's attending physician and inform consent form patient or family.

Exclusion Criteria

• Use Antibiotics over 24 hrs（only SIRS group）.
• Active bleeding.
• Pregnancy.
• Active Cancer (refer to malignancy which is recently diagnosed, under treatment, or relapsed)
• VS or Subject or Family refuse

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The present study will focus on testing 'biological markers' to identify patients with sepsis and acute lung injury in early stage.	72 hrs

Trial Locations

Locations (1)

Department of Intensive Care Medicine; Chi Mei Medical Center; 🇨🇳 Tainan, Taiwan