Obtención de un Panel de puntuación ("Score System") Para la predicción de Riesgo Individualizado y la detección Precoz de Carcinoma Hepatocelular (HCC) en Sujetos Coinfectados VIH/VHC
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acquired Immunodeficiency Syndrome Virus
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Sera inflammatory markers
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The aim of this study is to establish a clinical score panel based on clinical, molecular and genetic parameters that allow us to stratify and obtain an early detection of patients with an increased risk of developing hepatocellular carcinoma (HCC).
Detailed Description
Transversal study design like a "proof of concept". Primary objective: The main objective is try to stablish a descriptive panel (first phase of a score system) based in the conjunction or sum of several clinical and laboratory parameters (molecular and genetic factors). The aim is to detect in a fast, early and successful way those patients that presents a high risk to develop an hepatocellular carcinoma (HCC) in the future in a specific population: HIV and HCV coinfected patients. The establishment of this panel will allow clinicians set up a correct treatment decreasing the probability of liver cirrhosis and HCC.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Human immunodeficiency virus chronic infection
- •Hepatitis C virus chronic infection
- •No other liver viral coinfections
Exclusion Criteria
- •Alcohol consume
- •Immunosuppressor or immunoactive treatment
Outcomes
Primary Outcomes
Sera inflammatory markers
Time Frame: 1 day (Routine visit to normal following in Infectious Disease Department)
Inflammatory markers will be measure used a Enzyme-linked Immunosorbent Assay
Secondary Outcomes
- Sera apoptotic markers(1 day (Routine visit in disease following at Infectious Disease Department))