NCT05658835招募中不适用
Interest of Molecular Analysis of Cerebral Thrombi in Determining the Prognosis and Etiology of Cerebral Infarction
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 311
- 试验地点
- 4
- 主要终点
- Determination and validation of molecular signatures, obtained by LC-MS analysis of cerebral thrombi, predictive of the excellent clinical prognosis
研究概览
简要总结
The MATISSE (Molecular Analysis of Thrombus for Ischemic Stroke prognosis and Etiology) project evaluates the hypothesis that the molecular composition of cerebral thrombus in metabolites, lipids, and proteins conditions the clinical prognosis at 3 months of the infarction and informs on its etiological subtype
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female 18 years of age or older;
- •Patient with a cerebral infarction documented by brain imaging who received endovascular treatment by mechanical thrombectomy;
- •Patient for whom it was possible to collect cerebral thrombus for LC-MS analysis during mechanical thrombectomy:
- •Patient who was informed of the study and formulated a non-opposition to participation. If not, patient for whom a relative was informed and formulated a non-opposition.
排除标准
- •Patient with a cerebral infarction documented by cerebral imaging, having benefited from an endovascular treatment with mechanical thrombectomy that did not allow the extraction of a cerebral thrombus.
- •Protected persons (articles L1121-5, L1121-6 and L121-8 of the Public Health Code): pregnant or breast-feeding women, persons deprived of liberty, under guardianship or curatorship
结局指标
主要结局
Determination and validation of molecular signatures, obtained by LC-MS analysis of cerebral thrombi, predictive of the excellent clinical prognosis
时间窗: 3 months after the cerebral infarction
Rankin score (0 to 6, 6 meaning worse outcome)
次要结局
- Use of thrombolytic therapy in the acute phase(Before thrombectomy)
- Positive infarct growth after successful recanalization(Between 24 and 48h after the thrombectomy)
- Severe intracranial hemorrhage(3 months after the cerebral infarction)
- Death(3 months after cerebral infarction)
- Patient exposure to peak outdoor air pollution(96 hours before cerebral infarction)
- Early Neurological Deterioration(24 hours after recanalization treatment)
- Determination and validation of molecular signatures, obtained by LC-MS analysis(3 months after the cerebral infarction)
- Recovery of autonomy in walking(7 days after the cerebral infarction)
- Determination of molecular signatures predictive on successful recanalization after mechanical thrombectomy(Right after the thrombectomy)
研究者
研究点 (4)
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