Kuvan®'s Effect on the Cognition of Children With Phenylketonuria

Phase 4

Completed

• Conditions: Phenylketonuria
• Interventions: Drug: Kuvan®

• Registration Number: NCT01965912
• Lead Sponsor: BioMarin Pharmaceutical

Brief Summary

The study is a single-cohort, interventional, open-label trial to evaluate long-term neurocognitive (NC) outcomes in children aged 4 to 5 years with phenylketonuria (PKU) treated with Kuvan® and Phenylalanine-restricted diet over a period of 7 years.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-10-16
• Study First Submitted QC: 2013-10-16
• Study First Posted: 2013-10-18
• Primary Completion: 2023-01-04
• Study Completion: 2023-01-04
• Status Verified: 2023-03
• Last Update Submitted: 2023-04-21
• Last Update Posted: 2023-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Male or female outpatients, 4 to 5 years of age (greater than or equal to 4 and less than 6) at the time of informed consent form signature by parent(s) or guardian(s)

• Confirmed clinical and biochemical diagnosis of PKU, including at least two separate blood phenylalanine levels greater than or equal to 400 micromole per liter (mcmol/L)

• Defined pre-Kuvan®/-tetrahydrobiopterin (BH4) dietary phenylalanine tolerance consistent with the diagnosis of PKU

• Responsive to Kuvan®/BH4:

  • For subjects currently treated with Kuvan®/BH4 at Screening: subject is a responder as per Investigator judgment based on documented effect of Kuvan®/BH4 on phenylalanine levels and/or phenylalanine tolerance
  • For subjects not treated with Kuvan®/BH4 at Screening: a response test has been performed during Screening or is available from the subject's medical records and satisfies the 3 following criteria: a decrease in blood phenylalanine levels of at least 30 percent was observed after at least 24 hours with a dose of at least 10 mg/kg/day

• Intelligence Quotient (IQ) greater than or equal to 70, as assessed with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI)-III, 2nd part

• Good adherence with dietary treatment (including prescribed dietary phenylalanine restriction and prescribed amounts of phenylalanine-free protein supplements and low-phenylalanine foods), as assessed by the Investigator

• Well-controlled phenylalanine levels, as assessed by a minimum of 75 percent of phenylalanine levels within the target recommended in each centre during the previous 3 months

• Low phenylalanine diet started within the first 3 weeks of life

• Parent(s) or guardian(s) willing to comply with all study procedures, maintain strict adherence with the diet, and willing and able to provide written, signed informed consent before any trial-related activities are carried out, as well as ability of child to comply with trial procedures

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Exclusion Criteria

• Known hypersensitivity to Kuvan® or its excipients
• Known hypersensitivity to other approved or non-approved formulations of BH4
• Previous diagnosis of BH4 deficiency
• Current use of methotrexate, trimethoprim or other dihydrofolate reductase inhibitors
• Current use of medications that are known to affect nitric oxide synthesis, metabolism or action
• Current use of experimental or unregistered drugs (other than sapropterin/BH4) that may affect the study outcomes or use of such agents within 30 days prior to Screening
• Concurrent use of levodopa
• Concurrent disease or condition that would induce repeatedly catabolic situations, or interfere with the trial participation, diet, or NC development, as assessed by the Investigator
• Any condition that, in the view of the Investigator, renders the subject at high risk for failure to comply with treatment or to complete the trial
• Participation in a clinical trial investigating any other agent than Kuvan® within the past 30 days

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Kuvan®	Kuvan®	-

Primary Outcome Measures

Name	Time	Method
Mean Full Scale Intelligence Quotient (FSIQ) Score of the Wechsler Intelligence Scale for Children (WISC)-IV	Year 7

Secondary Outcome Measures

Name	Time	Method
Height compared to the World Health Organization (WHO) Growth Standards	up to 7 years
Weight compared to the World Health Organization (WHO) Growth Standards	up to 7 years
Blood levels of tyrosine, tryptophan, pre-albumin and methylmalonic acid	up to 7 years
Intelligence Quotient (IQ) score and sub-scores such as, verbal IQ, performance IQ, Full Scale Intelligence Quotient (FSIQ) of Wechsler Preschool and Primary Scale of Intelligence (WPPSI)-III	Baseline
Intelligence Quotient (IQ) score and sub-scores such as verbal comprehension, perceptual reasoning, working memory, and processing speed indexes and Full Scale Intelligence Quotient (FSIQ) of the Wechsler Intelligence Scale for Children (WISC)-IV	up to 7 years
Change from Baseline in FSIQ score at 2, 4 and 7 years	Baseline, and Year 2, 4 and 7
Dietary Phenylalanine tolerance	up to 7 years
Phenylalanine levels	up to 7 years
Index of Dietary Control (IDC)	up to 7 years
Percentage of tablets taken to assess treatment compliance	up to 7 years
Distribution of phenylalanine hydroxylase (PAH) genotype	Baseline
Number of subjects with Adverse Events and Serious Adverse Events	up to 7 years

Trial Locations

Locations (6)

Research site - Bambino Gesu; 🇮🇹 Roma, Italy

Research site; 🇬🇧 Bristol, United Kingdom

Research site - La Sapienza; 🇮🇹 Roma, Italy

Research Site; 🇪🇸 Barcelona, Spain

Research Site - Evelina; 🇬🇧 London, United Kingdom

Research site - GOSH; 🇬🇧 London, United Kingdom