EUCTR2009-015776-95-AT进行中（未招募）1 期
Effects of vitamin D supplementation in coronary artery disease patients with postchallenge hyperglycemia and vitamin D deficiency on endothelial function and insulin sensivitivity
niversitätsklinik für Innere Medizin, Klinische Abteilung für Endokrinologie und Nuklearmedizin0 个研究点开始时间: 2010年3月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •- Age 40-75
- •- Postchallenge hyperglycemia (2h value in oral glucose tolerance test above 139mg/dl, normal fasting glucose)
- •- Angiographically verified coronary artery disease (>50% stenosis)
- •- Serum 25-OH- vitamin D < 20 ng/ml in winter/spring/autumn and <25 ng/ml during june-september
- •- Stable antihyptertensive therapy in the last 3 month
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Acute coronary syndrome or cerebrovascular event within the previous 1 month
- •BMI > 40 kg/m²
- •Serum creatinine >2.5 times the upper limit of normal
- •GOT or GPT > 3 times the upper limit of normal
- •Heart failure > NYHA class II
- •Uncontrolled hypertension (>160/100 mmHg)
- •New onset of statins, ACE-inhibitors or ARBs within the previous 4 weeks
- •History of urolithiasis
- •Hypercalaemia
- •Major psychiatric disorders
- •Ongoing treatment with spironolactone, canrenoate, eplerenone, amiloride, triamteren and aliskiren.
- •immunosuppressive therapy
- •glucocorticoid therapy
- •ongoing chemotherapy
- •any other disease with an estimated life expectancy below 1 year.
研究者
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终止
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