Sarcopenic Obesity as Risk Factor for Insulin Resistance in the Elderly
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcopenic Obesity
- Sponsor
- University of Central Florida
- Enrollment
- 97
- Locations
- 1
- Primary Endpoint
- To explore the correlation of sarcopenia and obesity on insulin resistance
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Ageing is associated with progressive and generalized loss of muscle mass and muscle function, also known as Sarcopenia. Increasingly, obesity has become a compounding factor in ageing-related sarcopenia. The coexistence of obesity and sarcopenia is termed sarcopenic obesity (SO). Older adults with SO are at higher risks of developing diabetes, hypertension, stroke, cardiovascular diseases, and cognitive dysfunction than those older adults who suffer from sarcopenia alone or obesity alone. However, there is insufficient information with regard to the interplay between obesity and sarcopenia. The primary objective of this study is to investigate the impact of SO on insulin resistance in people aged 65-85. Our hypothesis is that SO positively influences insulin resistance in the elderly. We propose to investigate sarcopenia and obesity as risk factors for insulin resistance in the geriatric (65-85 years old) population.
Investigators
Eligibility Criteria
Inclusion Criteria
- •This study will include both male and females aged 65-85 years.
Exclusion Criteria
- •Lack capacity to consent for the study, or have moderate or severe cognitive impairment;
- •Have difficulty ambulating as evidenced by any one of the following:
- •Difficulty climbing 10 steps without resting;
- •Restricted to a wheelchair
- •Have difficulty performing basic activities of daily living;
- •Have had treatment for cancer in the prior 3 years;
- •Have history of cachexia;
- •Have a history of heart failure;
- •Have a permanent pacemaker in situ (due to magnetic resonance scanning);
- •Have an implanted cardioverter-defibrillator (ICD) in situ;
Outcomes
Primary Outcomes
To explore the correlation of sarcopenia and obesity on insulin resistance
Time Frame: 2 years
Secondary Outcomes
- To explore the correlation of sarcopenic obesity and glucometabolic and cardiovascular risk.(2 years)
- To explore the correlation between muscle strength and memory loss(2 years)