Metabolic health in neurodegenerative diseases - implications of metabolic characteristics and gut microbiome

Recruiting

Conditions: G20
G30
E88.9
Parkinson disease
Alzheimer disease
Metabolic disorder, unspecified

Registration Number: DRKS00030597

Lead Sponsor: Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

•BMI 18,5-39,9 kg/m²
•Non-smoker (for at least 3 months)
written declaration of consent for participation in the study.
•Diagnosis Parkinson disease or Alzheimer disease

PD cohort:
•PD based on clinical diagnosis according to Brain Bank criteria(Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinico-pathological study of 100 cases. JNNP 1992;55:181-184.)
•Hoehn & Yahr stadium 1-3

AD cohort
•Clinical and biomarker-based diagnosis with Alzheimer's pathology based on typical CSF findings
Mixed dementia with a vascular component (up to Fazekas II) is permitted.

Exclusion Criteria

•Taking medications that affect glucose metabolism
•chronic hepatic diseases, gastrointestinal diseases, chronic inflammatory diseases or other severe diseases
•antibiotic therapy 3 weeks before the start of the study
•Planned lifestyle changes
•regular intake of supplements
•drug abuse
•participation in another clinical trial simultaneously/in the last 30 days

PD cohort:
•Atypical PD syndromes
•DBS care
•severe motor fluctuations

AD cohort:
•Dementia of unclear origin
•Heavy vascular part (Fazekas III)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolic differences

Secondary Outcome Measures

Name	Time	Method
intestinal microbiome (composition, diversity), concentration of various intestinal hormones, parameter of intestinal permeability, parameter of glucose and lipid metabolism, parameter of inflammation, neuroinflammation and antioxidative defence, short chain fatty acids (SCFAs), amino acids, serotonin, electrolytes. <br><br>Further parameters: anthropometrics (body weight, body height, waist and hip ratio, body composition (BodPod), resting energy expenditure (QuarkRMR), cognition, transit time, nutritional behaviour, physical activity, socio-economic status, chronobiology, gynaecological history.<br><br>Security parameters: small blood count, parameters of renal and hepatic function (GOT, GPT, GGT, bilirubin, uric acid, urea, creatinine).<br>