The effect rhFSH drug in infertile me
Phase 1
Recruiting
- Conditions
- oligospermia.????????? ????? ?????? XIVn00-n99
- Registration Number
- IRCT20170923036334N2
- Lead Sponsor
- Islamic Azad University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
Oligozospermia infertile men
Exclusion Criteria
Men with varicocele, history of varicoceles surgery, systemic disease or taking medication for systemic disease, chemotherapy or radiotherapy history, anatomical problems in the genitals, including testicular atrophy, treatment with antidepressants, are excluded.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sperm parameters. Timepoint: In this study, the evaluation of sperm parameters before and after rhFSH is evaluated and the rate of use of rhFSH is three months. Method of measurement: Clinical analysis of semen standard for sperm parameters with the usual laboratory method and optical microscope according to WHO-2010 WHO criteria.;DNA Damage. Timepoint: In this study, the evaluation of DNA damage before and after taking rhFSH is measured and the rate of use of rhFSH is three months. Method of measurement: DNA damage is done using the SDF laboratory kit and optical microscope.;The amount of hormone FSH. Timepoint: In this study, the amount of FSH is measured before and after the administration of the drug, and the rate of use of rhFSH is three months. Method of measurement: Measurement of FSH levels is done by ELIZA commercial kits.
- Secondary Outcome Measures
Name Time Method Check fertilization rates. Timepoint: One day after sperm injection into the oocyte cytoplasme . Method of measurement: Fertilization can be seen with an inverted microscope.;Quality of the embryo. Timepoint: Three days after sperm injection into oocyte cytoplasm. Method of measurement: Evaluating the quality of the embryo is based on the number of cells and the number of blastomers and the fragmentation of the blastomers and is observed with the Invert microscope.;Pregnancy. Timepoint: 14 days after the transfer of the embryo into the uterus. Method of measurement: Pregnancy testing is done by giving beta-HCG.