Effect of vitamin C with bioflavonoids supplementation on immune cell function after low-intensity exercise in patients with poor glycemic control type II diabetes mellitus
- Conditions
- Type 2 diabetic patients especially in poor glycemic control (HbA1c ≥ 8.5% or ≥ 69 mmol/mol)patient with type 2 diabetes
- Registration Number
- TCTR20180227001
- Lead Sponsor
- The Royal Golden Jubilee (RGJ) Ph.D. Programme, Thailand Research Fund (TRF). (PHD/0016/2557)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 14
Poor glycemic control T2D patients (45-60 years old) obtained from Khon Kaen hospital and Srinagarind hospital, Khon Kaen province in Thailand after providing written informed consent. There are eight participants for determination of the lymphocyte subpopulations and four from eight participants for IL-17 production. All participants were diagnosed T2D for at least a year before enrollment and present HbA1c levels ≥ 8.5% (HbA1c levels ≥ 69 mmol/mol). Individuals with T2D were medicated with oral hypoglycemic medicine (mostly metformin) and not participated for at least 6 months prior in any regular exercise program.
Exclusion criteria were liver, kidney, cardiovascular disease, chronic infections (HIV, TB, Hepatitis), changed types and doses of anti-hypertensive, hypoglycemic or lipid-lowering drugs prescription, regularly supplemented with antioxidant, blood pressure higher than 140/90 mmHg, abnormal resting EKG, neuromuscular disorders and orthopedic problems
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of oral CB supplementation on PMN function after low-intensity exercise 10/07/2017 Flow cytometry,N/A N/A N/A
- Secondary Outcome Measures
Name Time Method Effect of CB supplementation and exercise on cell subpopulation and IL17 production 10/07/2017 Flow cytometry