ROLE OF PROBIOTICS IN MANAGEMENT OF ACUTE DIARRHOEA IN CHILDREN LESS THAN 5 YEARS
- Conditions
- Health Condition 1: null- All children aged between 6 months to 5 years with acute diarrhoea ( 7 days duration) visiting the outpatient department or emergency wards will be eligible for inclusion in the study.
- Registration Number
- CTRI/2011/10/002067
- Lead Sponsor
- ala Lajpat Rai Memorial Medical College Meerut
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
All children aged between 6 months to 5 years with acute diarrhoea (less than 14 days duration) visiting the outpatient department (OPD) or emergency wards will be eligible for inclusion in the study.
Diarrhoea will be defined if child is having three or more loose stools in the last 24 hours.
1.Severe malnutrition (Weight for length 3 SD)
2.Dysentery (Presence of visible blood in stools)
3.Clinical evidence of coexisting acute systemic illnesses (meningitis, sepsis, pneumonia)
4.Clinical evidence of chronic disease (e.g. chronic liver disease, chronic renal disease, nephrotic syndrome)
5.Known case of chronic gastrointestinal diseases like celiac disease or inflammatory bowel disease.
6.Use of probiotics in the previous three weeks
7.Use of antibiotics or any antidiarrhoeal medication for the current episode of diarrhoea.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Duration of diarrhoea (time in hours from enrolment to the last abnormal (loose or liquid) stool. Last abnormal stool will be defined when the child passes normal stool or no stool for next 24 hours. <br/ ><br>2.Stool consistency as evaluated on a score. Faeces will be graded as 1 (normal), 2 (loose), 3 (semiliquid), and 4 (liquid)5. <br/ ><br>Timepoint: probiotic lactobacillus GG given for 5 days at the dose of 10 billion CFU/day <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Number of loose stools per day during entire episode. <br/ ><br>2.Duration of vomiting. <br/ ><br>3.Duration of hospital stay. <br/ ><br>4.Any adverse effects <br/ ><br>Timepoint: patients is monitored till his diarrhoea is relieved