Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery

Terminated

• Conditions: Reperfusion Injury

• Registration Number: NCT02394405
• Lead Sponsor: Moscow Regional Research and Clinical Institute (MONIKI)

Brief Summary

Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-02-12
• Study Start: 2015-03
• Study First Submitted QC: 2015-03-16
• Study First Posted: 2015-03-20
• Primary Completion: 2018-03
• Study Completion: 2018-12
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-13
• Last Update Posted: 2019-08-15

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• shedduled CABG

Exclusion Criteria

• stroke befor surgery
• miocardial infarction 6 monthes befor surgery
• dementia
• liver cirrhosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assay of mtDNA	from baseline whithin 72 hours

Secondary Outcome Measures

Name	Time	Method
Assay of S100b-protein	from baseline whithin 72 hours
Assay of carbonilated proteins	from baseline whithin 72 hours
Assay of nitrotyrosine	from baseline whithin 72 hours
Assay of oxy-LDL	from baseline whithin 72 hours
Assay of nDNA	from baseline whithin 72 hours

Trial Locations

Locations (1)

Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy; 🇷🇺 Moscow, Russian Federation