Peripartum Bacteruria and Urinary Tract Infections (UTI)

Not Applicable

• Conditions: Urinary Tract Infection

• Registration Number: NCT00121797
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

In the last years urinary tract infections (UTI) and pyelonephritis have been the most common reason for readmission to our hospital after birth. UTI is know to be one of the leading causes of postpartum fever affecting about 3%-8% of all postpartum women.

The investigators hypothesize that collecting urine cultures pre- and postnatally may help identify women at risk for developing UTI, while treating women with positive cultures could decrease the rehospitalization rate due to postpartum fever. Collecting data during delivery may help identify women at risk for this complication.

Detailed Description

The study is planned as a randomized controlled study with 500 women in each arm. The study group will have pre and post labor urine cultures taken, and the risk factors during delivery will be documented, while the control group will have no cultures taken, as the common practice prior to the study.

Women with positive cultures will be contacted by telephone, and antibiotic treatment recommended according to bacteria sensitivity. All women will be contacted by telephone 1 month post partum and data regarding urinary tract symptoms and need for hospitalization, will be collected. The rehospitalization rate will be documented and compared between the two groups.

The assumption is that routine urine culture to women in the peripartum period may reduce the UTI rate and hospitalization after delivery.

Study Timeline

• Study Start: 2004-01
• Study Completion: 2005-06
• Status Verified: 2005-07
• Study First Submitted: 2005-07-17
• Study First Submitted QC: 2005-07-17
• Study First Posted: 2005-07-21
• Last Update Submitted: 2006-11-06
• Last Update Posted: 2006-11-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 1000

Inclusion Criteria

• Parturients planned for vaginal delivery

Exclusion Criteria

• Parturients receiving antibiotic treatment during delivery or in the week before

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Rate of rehospitalization for postpartum fever
Incidence of UTI in the early puerperium

Trial Locations

Locations (2)

Obs&Gyn Hadassah Ein-Kerem Medical center; 🇮🇱 Jerusalem, Israel

Clinical microbiology, Hadassah Ein-Kerem Medical centre; 🇮🇱 Jerusalem, Israel