Assessment of central airways mechanics using Magnetic Resonance Imaging (MRI) and bronchoscopy: a compariso
Completed
- Conditions
- 10010613tracheo malacia
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Indication for bronchoscopy as decided by the treating pediatric chest physician
Aged 8 years or above
Ability to perform spirometry and spirometry controlled or technician controlled MRI
Informed consent from the parents/ guardians
Exclusion Criteria
Any contra indication for MRI
In the case any contra indications to administer bronchodilator, this part of the protocol will be omitted
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the sensitivity and specificity of MRI as a<br /><br>diagnostic tool for static and dynamic assessment of airway collapsibility in<br /><br>children. We will determine sensitivity, specificity, PPV and NPV of our MRI<br /><br>protocol compared to flexible bronchoscopy to assess airway collapsibility, the<br /><br>current gold standard for airway assessment in pediatric patients. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameter is the severity scores of airway collapsibility using<br /><br>MRI and bronchoscopy. Concordance between MRI and bronchoscopy airway<br /><br>collapsibility severity scores will be assessed. Airway collapsibility for both<br /><br>MRI and bronchoscopy will be scored both with categorical and continuous<br /><br>variables.</p><br>