Midodrine for the prevention of perioperatIve hypotensio

Phase 4

• Conditions: Perioperative Hypotension; Anaesthesiology - Other anaesthesiology; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12620000246987
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-02-26
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Age >/= 70 years
ASA 3 or 4
Major body cavity surgery, joint arthroplasty, major vascular surgery or spinal surgery
Expected surgery duration > 2 hours
Planned hospital stay >/= 1 night

Exclusion Criteria

Emergency or inpatient surgery
Pregnancy
Age < 70 years
Cardiac or intracranial neurosurgery
Planned critical care admission
Preoperative SBP >160mmHg
Known chronic urinary retention
Known hypersensitivity to midodrine
Other contraindication to midodrine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative hypotension<br>-Incidence of systolic blood pressure <100mmHg as measured using an automated or manual sphygmomanometer and recorded in the electronic medical record.[0-48HRS postoperatively ];Postoperative rapid response team call - this is a binary outcome it is either activated or not activated. A rapid response team call is made when a patient meets pre-specified call criteria as outlined in the following article:<br>Jones DA, DeVita MA, Bellomo R. Rapid-response teams. N Engl J Med 2011; 365: 139-46[0-48HRS postoperatively ]