Study on the effectiveness of a low histamine diet and diamino oxidase enzyme supplementation in patients with histamine intolerance

Not Applicable

• Conditions: Symptoms associated with histamine intolerance due to DAO deficiency; Not Applicable

• Registration Number: ISRCTN64888465
• Lead Sponsor: DR Healthcare España, S.L.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-09-06
• Last Update Posted: 19 September 2022
• Study Completion: 2025-06-07

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Adults over 18 years of age
2. Recent history of two or more symptoms associated with histamine intolerance (headache, dermatological, respiratory, and digestive)
3. Present altered plasma DAO enzyme activity and/or have any of the genetic variants of DAO deficiency:
3.1. SNP-type variants associated with reduced levels of DAO activity (oral mucosal smear or blood)
3.2. rs10156191
3.3. rs1049742
3.4. rs1049793
3.5. rs2052129
4. Not having started dietary treatment (low histamine diet/DAO enzyme supplementation) before starting the study

Exclusion Criteria

1. Food and/or environmental allergies
2. Have taken pharmacological treatment with antibiotics or probiotic supplements in the last month before the start of the study
3. Being pregnant

Study & Design

• Study Type: Interventional
• Study Design: Not specified