AI-Powered Research

* Age 62 * 75 or 18 * 30 years
* Right-handed, to be confirmed by using the Edinburgh handedness inventory (Oldfield, 1971).
* Good vision (on 1 meter distance), glasses are allowed

Exclusion Criteria

* History of skin diseases that could result in irritation of the skin underneath the electrodes
* History of epilepsy or a known case of epilepsy in a first degree relative
* Metallic implants in the brain
* Presence of cardiac pacemakers, implanted heart rhythm monitor, implanted defibrillator, cochlear implant or implanted brain electrodes
* Presence of severe or frequent headache
* Use of medication that alters the motor cortex excitability
* Use of medication that, according to the product information, can increase the chance of seizures.
* Use of any illegal drugs in the last month (relying on self-report)
* Pregnancy
* Had spinal surgery or have drains in their spinal cord or ventricles
* Other neurological disorders
* A history of cardiac conditions that interfere with physical load
* Severe depression
* A score on the Montreal Cognitive Assessment (MoCA) of 22 or lower, indicating mild cognitive impairment (Nasreddine et al., 2005). This tool has been extensively validated (e.g., Freitas, Simões, Alves, & Santana, 2013). YA will not be administered this questionnaire. See appendices for full questionnaire.
* Severe motor problems or limitations in using the fingers or arms, chronic joint pain, arthritis or rheumatism

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Participants will perform a sequence-learning task, performance on this task<br /><br>will provide the main outcome parameters. The participant uses a response box<br /><br>to learn to tap a 5-element sequence as many times as possible in a 3 minute<br /><br>time period. All right-hand fingers excluding the thumb are used. In total, 8<br /><br>blocks of 3 minutes tapping are included. In the fixed-sequence blocks<br /><br>(Baseline Sequence, and practice blocks 1 to 5), a fixed sequence is displayed<br /><br>continuously on the computer screen. In the random-sequence blocks (1 block<br /><br>before and 1 block after the fixed-sequence blocks), a new random sequence is<br /><br>to be performed after every sequence performance.<br /><br><br /><br>The main study parameter will be the number of sequences performed correctly,<br /><br>relative to the baseline sequence block, during each practice block. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameter will be the number of random sequences performed<br /><br>correctly in the post-test random sequence block, relative to the baseline<br /><br>random sequence block.</p><br>