A COMPARISON BETWEEN INTRAVENOUS BOLUS DOSES OF MEPHENTERMINE AND NOREPINEPHRINE DURING SUBARACHNOID BLOCK FOR LSCS
Phase 3
- Conditions
- Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
- Registration Number
- CTRI/2022/10/046224
- Lead Sponsor
- DEPARTMENT OF ANAESTHESIOLOGY AND CRITICAL CARE JAWAHARLAL NEHRU MEDICAL COLLEGEAMUALIGARH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA GRADE 1 AND 2;
FULLTERM
NON LABORING
SINGLETON PREGNANCY
Exclusion Criteria
1.MULTIPLE PREGNANCIES
2.FETAL DISTRESS
3.PARTURIENTS HAVING CONTRAINDICATIONS TO SUBARACHNOID BLOCK LIKE LOCAL INFECTION, COAGULATION ABNORMALITIES OR ON ANTICOAGULANT MEDICATION
4.PARTURIENTS WITH HYPERTENSIVE DISORDERS OF PREGNANCY AND OTHER HIGH RISK PREGNANCIES, MEDICAL COMORBIDITIES, HEMOGLOBIN <8MG/DL
5.HEMODYNAMIC INSTABILITY
6.PARTURIENTS ON DRUGS WHICH CAUSE INTERACTIONS WITH THE STUDY DRUGS LIKE TRICYCLIC ANTIDEPRESSANTS, MONOAMINE OXIDASE INHIBITOR ETC
7.PARTURIENTS WITH HEIGHT/LENGTH <150CM OR >180CM
8.DRUG ALLERGIES
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MBER OF INTERMITTENT INTRAVENOUS BOLUS DOSES OF NOREPINEPHRINE OR MEPHENTERMINE REQUIRED TO TREAT SPINAL INDUCED HYPOTENSIONTimepoint: TIME (IN MINUTES) TAKEN FOR FIRST HYPOTENSIVE EPISODE & TIME (IN MINUTES) OF FURTHER EPISODES OF HYPOTENSION REQUIRING BOLUS DOSES OF NOREPINEPHRINE OR MEPHENTERMINE
- Secondary Outcome Measures
Name Time Method 1.Time of first hypotensive episode <br/ ><br>2.Number and timing of episodes of hypotension and reactive hypertension <br/ ><br>3.To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. <br/ ><br>4. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. <br/ ><br>5.To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min <br/ ><br> <br/ ><br>Timepoint: 1.Number and timing of episodes of hypotension and reactive hypertension <br/ ><br>2.To compare the number and timing of Bradycardia , Bradycardia requiring treatment and tachycardia. <br/ ><br>3. To note maternal complications shivering, headache vomiting/nausea and local tissue ischemia. <br/ ><br>4.To compare the effect of drugs on the fetus in both the groups : APGAR score at 1min & 5min <br/ ><br> <br/ ><br> <br/ ><br>