Comparing Acticoat and Collagen Dressings for Healing Donor Sites After Skin Grafts: A Study Summary

Recruiting

• Conditions: Disorder of the skin and subcutaneous tissue, unspecified,

• Registration Number: CTRI/2025/02/081073
• Lead Sponsor: All India Institute of Medical Sciences

Brief Summary

Split thickness skin grafts are now an essential method on the reconstructive ladder and a widely utilized technique for wound reconstruction. Graft donor site wounds create additional challenges due to various morbidities like delayed epithelialization, persistent bleeding, prolonged drainage, pain and scars. Hence care of skin graft donor site is of paramount importance to decrease various morbidities and enhance early wound healing. There is no ideal dressing materials recommended for the care of donor site. Acticoat is a nanocrystalline silver containing dressing material used in the management of various partial and full

thickness wounds. Collagen is a biomaterial that encourages wound healing through deposition and organization of freshly formed fibres and granulation tissue in the wound bed thus creating a good environment for wound healing. To our knowledge, there is no literature comparing the outcome of two modalities and hence our study may provide more insight to this aspect.

The hypothesis for the study is Application of acticoat dressing over split thickness skin graft donor site provide better wound healing than collagen dressing.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-02-20
• Study Start: 2025-10-03

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• All patients admitted under Department of Burns and Plastic Surgery AIIMS,Raipur undergoing split thickness skin grafting with a wound size more than 8cm2 2.
• Age above 18 years and below 60 years 3.
• Patients who are willing for post-operative follow-up.

Exclusion Criteria

• Pregnant women 2.
• Patient likely to undergo MRI (Magnetic Resonance Imaging) examination during the initial postoperative period with acticoat dressing insitu 3.
• Patients with inadequate nutritional status (Haemoglobin less than 9gm/dl, Total serum protein less than 5.5gm/dl, serum Albumin less than 3.5gm/dl) or other known illness that can delay wound healing.
• Patients and/ or relatives not giving informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TIME OF WOUND HEALING	2 WEEKS

Secondary Outcome Measures

Name	Time	Method
1. To compare the post-operative pain at the split thickness skin graft donor site after application of acticoat dressing versus collagen dressing during the dressing change	2. To compare the wound infection at split thickness skin graft donor site after acticoat dressing versus collagen dressing

Trial Locations

Locations (1)

All India Institute of Medical Sciences; 🇮🇳 Raipur, CHHATTISGARH, India

All India Institute of Medical Sciences

🇮🇳Raipur, CHHATTISGARH, India

Dr ABHIJITH V

Principal investigator

09400030251

sreevalsam456@gmail.com