In search for a blood marker for febrile seizures
Completed
- Conditions
- Febrile convulsionsFebrile seizures10039911
- Registration Number
- NL-OMON35098
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Patient suffers from complex febrile seizures and is between 3 and 10 years of age.
Control patients does not suffer from febrile seizures and is between 3 to 10 years of age.
Exclusion Criteria
If the patients suffer from another type of epilepsy
If they use antiepileptic medication
Less then three generations Dutch ancestors
Within 24h before the blood collection suffering from a FS or fever
Other neurological or metabolic disorders or general health problems
Control patient suffer from febrile seizures
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>mRNA and protein levels of FS1 will be measured, The mean level in the patient<br /><br>group will be compared with a control group. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The FS1 gene will be sequenced in patients and controls, to possibly find the<br /><br>mutation that is responsible for the expression change.<br /><br>Possible other genes in the FS1 pathway will be investigated</p><br>