A clinical study comparing the effect of protein solution with diuretic drug against diuretic drug alone in sick protein-deficient children with excessive body water
Not Applicable
- Conditions
- Health Condition 1: null- Critically ill Mechanically ventilated Hypoalbuminemic Children with Fluid Overload
- Registration Number
- CTRI/2017/10/010247
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
PICU stay > 48 hours
Age 2 month to 12 years
Mechanically ventilated
Presence of fluid overload
Decision by the treatment physician to achieve diuresis
Hypoalbuminemia (serum albumin < 2.5g/dL)
Exclusion Criteria
Hemodynamic instability at the time of recruitment or during preceding 12 hours
Children with severe acute malnutrition, cardiac disease, renal failure, liver failure, nephrotic syndrome or protein losing enteropathy Receipt of albumin transfusion in preceding 48 hours
Receipt of furosemide in the preceding 12 hours
History of adverse reaction to prior albumin transfusion
Hemoglobin < 7g/dl
Serum Na+ > 155mEq/l and cannot be corrected prior to enrollment
Serum K+ < 2.5mEg/L and cannot be corrected prior to enrollment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method