Duration of Doxycycline Treatment in EM Patients
Not Applicable
Completed
- Conditions
- Erythema Chronicum Migrans
- Interventions
- Drug: Controls without a history of lyme disease.
- Registration Number
- NCT03153267
- Lead Sponsor
- University Medical Centre Ljubljana
- Brief Summary
The purpose of this study is to compare the efficacy of 7-day versus 14-day doxycycline treatment in patients with erythema migrans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- solitary erythema migrans
Exclusion Criteria
- pregnancy or lactation
- immunocompromised
- serious adverse event to doxycycline
- taking antibiotic with antiborrelial activity within 10 days
- multiple erythema migrans or extracutaneous manifestations of lyme borreliosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description EM-7 days doxycycline Doxycycline 100 MG Oral Tablet bid, 7 days - EM-14 days doxycycline Doxycycline 100 MG Oral Tablet bid, 14 days - Controls Controls without a history of lyme disease. -
- Primary Outcome Measures
Name Time Method Treatment outcome in patients treated for erythema migrans with doxycycline for 7 or 14 days At 12 months after enrollment. Objective sequelae and post-treatment subjective new or increased symptoms (NOIS) in patients treated for erythema migrans with doxycycline for 7 or 14 days.
- Secondary Outcome Measures
Name Time Method Comparison of nonspecific symptoms in patients with erythema migrans and control subjects At 12 months after enrollment. Number of patients after treatment with doxycycline for 7 or 14 days for erythema migrans and number of control subjects (without a history o Lyme borreliosis) with nonspecific symptoms.
Trial Locations
- Locations (1)
University Medical centzer Ljubljana
🇸🇮Ljubljana, Slovenia