High Flow Nasal Oxygen Therapy in COVID-19 patients
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2020/12/030015
- Lead Sponsor
- All India Institute of Medical Sciences Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients tested COVID-19 positive by Reverse Transcriptase Polymerase Chain Reaction (rt-PCR) test and admitted in Corona Critical Care wards at AIIMS, Jodhpur till January 31, 2021
- Requiring the use of High FLow Nasal Oxygen Therapy
Exclusion Criteria
- Patients who / whose proxies refuse to consent to use of their data for research
- Patients who were on non-invasive / invasive mechanical ventilation before the use of HFNC (High Flow Nasal Cannula)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of patients who did not require intubation and invasive mechanical ventilation by using HFNC as a rescue modality to manage hypoxemia in rt-PCR confirmed Covid-19 patients admitted to the critical care settingTimepoint: At the time of initiating HFNC and daily at 24hrs intervals after till a positive / negative outcome is reached
- Secondary Outcome Measures
Name Time Method The 28 days all-cause mortality and length of ICU/CCCU stay in these patientsTimepoint: Time of discharge and 28 days post admission;The blood gas parameters (Po2 and PFR) of patients taken on HFNC and their trends over time of useTimepoint: At the time of initiating HFNC and daily at 24hrs intervals after till a positive / negative outcome is reached;The duration of HFNC requiredTimepoint: At the time of initiating HFNC and daily at 24hrs intervals after till a positive / negative outcome is reached;The validity of using ROX and modified ROX indices as a predictor of intubation and hence failure of HFNCTimepoint: 2hrs, 6hrs, 12hrs and subsequently at 24hr intervals post initiating HFNC use;To compare the data among various demographics and patients with varied comorbiditiesTimepoint: At the time of initiating HFNC and daily at 24hrs intervals after till a positive / negative outcome is reached