Point-of-Care Multiplex for Adult Patients With Severe Community-acquired Pneumonia

Not Applicable

Interventions: Diagnostic Test: Provide the panel report to the primary care physician

Brief Summary: Clinical Impact on Point-of-Care Multiplex PCR Testing for Critically Ill Adult Patients With Community-acquired Pneumonia - A cluster randomization study in ICU units within one medical center.

Detailed Description: Point-of-Care Multiplex PCR Testing could narrow down the pathogens causing severe community-acquired pneumonia(CAP). Our hypothesis is that the result of Point-of-Care Multiplex PCR Testing could help primary physician to reduce antibiotics use.

Recruitment & Eligibility

Inclusion Criteria

Adult patients (age >20 y/o)
ICU admission for acute respiratory failure due to community-acquired pneumonia by clinical diagnosis
Treatment with endotracheal Intubation

Exclusion Criteria

Aspiration pneumonia (including witnessed aspiration and chronic bedridden status)
Nosocomial infection

Arm && Interventions

Group	Intervention	Description
Reporting	Provide the panel report to the primary care physician	check point-of-care Multiplex PCR for pneumonia pathogens and report results to primary care physician

Primary Outcome Measures

Name	Time	Method
Intravenous antibiotic-free day within 14 days	up to 14 days	days without intravenous antibiotics within 14 days

Secondary Outcome Measures

Name	Time	Method
Intravenous antibiotic-free day within 21 days	up to 21 days	days without intravenous antibiotics within 21 days
ICU stay	up to 21 days	days of stay in ICU
Antibiotic-free day within 21 days	21 days	days without antibiotics within 21 days
Ventilator-free day within 28 days	up to 28 days	days without intravenous antibiotics within 28 days

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