Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)

• Conditions: Bipolar Disorder; Autism Spectrum Disorder

• Registration Number: NCT02423499
• Lead Sponsor: University Hospital, Tours

Brief Summary

The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-04-03
• Study First Submitted QC: 2015-04-17
• Study First Posted: 2015-04-22
• Study Start: 2015-05-19
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-11
• Last Update Posted: 2021-05-12
• Primary Completion: 2021-05-26
• Study Completion: 2021-05-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• For all participants:

  • Age between 18 and 50 years
  • Normal vision (or corrected)
  • Absence of neurological disorder (epilepsy , head trauma, ... )
  • Ability to understand information about the protocol
  • Informed and signed consent
  • normal mood (euthymia)
  • normal or high intelligence

• Subjects with ASD:

  • Subjects with an autism spectrum disorder according to the DSM-5
  • The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) .

• Subjects with bipolar disorder:

  • Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5
  • The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) .

• Healthy volunteers:

  • Inclusion after checking the national register of healthy volunteers
  • No history of disease of the central nervous system or psychiatric disorder
  • No family history of ASD or BD in the first degree
  • Lack of psychotropic medication or current cardiotropic
  • Lack of psychiatric disorder on Axis I MINI 6.0
  • AQ Score < 32

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session	average 1 hour

Secondary Outcome Measures

Name	Time	Method
Subjective emotional response during emotion elicitation in a laboratory session	average 1 hour
Facial emotional response during emotion elicitation in a laboratory session	average 1 hour
Experience sampling method in real life during a week (emotions, activities, social context, burden)	within the first 7 days after inclusion
Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry)	within the first 24h approx. after inclusion

Trial Locations

Locations (1)

LEMAIRE; 🇫🇷 Tours, France