High-intensity Interval Training Versus Moderate Continuous Training in Heart Transplant Recipients With Impaired Chronotropic Response: A Randomized Controlled Crossover Trial.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Transplant Recipients
- Sponsor
- Bispebjerg Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- VO2peak
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this study was to examine the effects of high intensity aerobic interval training (AIT) versus moderate continuous training (CON) in heart transplant recipients.
Detailed Description
Clinically stable heart transplant recipients \> 12 month or more after HTx, age \> 18 years, willing and capable of giving written informed consent for study participation and anticipated to be able to participate in the study for 12 months were included from the Heart Centre, Rigshospitalet, Copenhagen University Hospital. Patients were excluded due to unstable condition or postoperative complications, recent severe rejection episodes (\>H1R \< 3 month), physical disabilities which prevent participation and re-transplantation or multi-organtransplantation.
Investigators
Christian Dall
Associate professor
Bispebjerg Hospital
Eligibility Criteria
Inclusion Criteria
- •stable Heart transplant recipients \> 12 month or more after HTx, age \> 18 years,\<
- •willing and capable of giving written informed consent for study participation.
Exclusion Criteria
- •unstable condition postoperative complications, recent severe rejection episodes (\>H1R \< 3 month), re-transplantation or multi-organtransplantation.
Outcomes
Primary Outcomes
VO2peak
Time Frame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
baseline test before randomization 1. follow-up after 12 weeks of exercise 2. follow-up after 5 month washout. 3. follow-up after second 12 weeks period of exercise.
Secondary Outcomes
- Endothelial function (endoPAT)(baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).)
- Quality of Life (QoL)SF-36(baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).)
- Bloodsamples/biomarkers.(baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).)
- HADS-a, HADS-d anxiety and depression(baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).)
- augmentation index (AI), endoPAT(baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).)