Investigation of Fat and Carbohydrate Oxidation During Moderate Versus Vigorous Intensity Exercise in Healthy Volunteers With Sedentary Lifestyle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Optimal workload
研究概览
简要总结
Exercise is widely suggested as an important lifestyle change for weight loss, however, the optimal level of intensity moderate versus vigorous remains unclear. It is known that in athletes, during very high-intensity exercise, fat oxidation is decreased and energy is gained mainly from carbohydrate utilization. The aim of this study is to find an optimal workload based on fat oxidation rate during exercise in volunteers with a sedentary lifestyle.
详细描述
It is planned to recruit 12 healthy volunteers with a sedentary lifestyle in the study group. Since different regimens (fed, fasted and moderate versus vigorous) will be compared in the same subjects, no control group is necessary. Subjects will perform a cycling test with 5 min incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load will be selected after the incremental intensity exercise). The expiration of carbon dioxide (CO2) and consumption of oxygen (O2) will be measured, to determine the total fatty acid and carbohydrate oxidation during cycling. Concomitantly, it is planned to measure blood lactate and glucose concentrations during exercise experiments as well as a wide range of blood biochemistry parameters before and after exercise.
The investigators expect to find optimal conditions for the sedentary population for burning of fat, which is the major source of energy during moderate-intensity exercise. Measurements of the fat and carbohydrate oxidation in healthy volunteers with a sedentary lifestyle will contribute to the understanding of exercise regimens for the most effective fat oxidation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sedentary lifestyle
- •BMI 20 - 30 kg/m2
- •Be able to attend the laboratory and willing to participate in necessary protocols
- •Be willing to undertake the duration of the exercise protocol (3 x 1 hour)
- •Have the capacity and willingness to provide informed consent (oral and written)
排除标准
- •Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.
- •History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis
- •Active Smokers
- •Pregnant women
研究组 & 干预措施
Exercise
Subjects will perform a cycling tests
干预措施: Exercise (Other)
结局指标
主要结局
Optimal workload
时间窗: 30 min accelerated load cycling exercise
The exercise workload (W) for optimal fat burning during exercise
Heart rate change
时间窗: 30 min accelerated load cycling exercise and 60 min optimal intensity cycling exercise
Change in heart rate (BPM) from rest to the optimal workload
次要结局
- Influence of fed and fasted state(30 min accelerated load cycling exercise)