Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair

Completed

• Conditions: Hypotension Drug-Induced; Blood Pressure
• Interventions: Drug: Sevoflurane; Drug: Etomidate

• Registration Number: NCT04865614
• Lead Sponsor: Heidelberg University

Brief Summary

The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase.

This retrospective cohort study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of catecholamines during the induction and the interventional procedure in patients undergoing interventional mitral valve repair.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-01
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01
• Study First Submitted: 2021-04-26
• Study First Submitted QC: 2021-04-26
• Study First Posted: 2021-04-29
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-25
• Last Update Posted: 2021-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

• Patients undergoing elective interventional mitral valve repair
• Sevoflurane or etomidate have been used for induction of anesthesia

Exclusion Criteria

• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sevoflurane group	Sevoflurane	Patients who received sevoflurane for induction of anaesthesia during interventional mitral valve repair (Mitraclip)
Etomidate group	Etomidate	Patients who received etomidate for induction of anaesthesia during interventional mitral valve repair (Mitraclip)

Primary Outcome Measures

Name	Time	Method
Post-induction hypotension	First 20 minutes after induction of anaesthesia	Hypotension in the first 20 minutes after induction of anesthesia

Secondary Outcome Measures

Name	Time	Method
Use of catecholamines	Length of procedure (Approximately 60 to 90 minutes in average)	Use of catecholamines during the procedure
Use of catecholamines after induction during the first 20 minutes after inductionafter induction	First 20 minutes after induction	Use of catecholamines during the first 20 minutes after induction of anaesthesia

Trial Locations

Locations (1)

Anästhesiologische Klinik (Universitätsklinikum Heidelberg); 🇩🇪 Heidelberg, Baden-Würtemberg, Germany