Effect of curcumin versus placebo on the improvement of sever traumatic brain injury
Phase 3
Recruiting
- Conditions
- Head injury.Crushing injury of head
- Registration Number
- IRCT20120215009014N305
- Lead Sponsor
- Hamedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 168
Inclusion Criteria
Age of 18 to 70 years,
Head trauma with past 24 hours,
Conscious level of 8 or less,
Candidate for craniotomy surgery
Exclusion Criteria
Pregnancy or breastfeeding,
Low blood pressure,
Absence of brain reflex,
Renal failure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Consciousness level. Timepoint: Daily for three weeks. Method of measurement: Using the Glasgow Coma Score (GCS).;Improvement of neurological defect. Timepoint: 3 and 6 months after the intervention. Method of measurement: With clinical examination.;Nervous system function. Timepoint: 3 and 6 months after the intervention. Method of measurement: Based on the Glasgow Outcome Score (GOS).;Brain edema. Timepoint: 3 weeks after the intervention. Method of measurement: Using CT scan.
- Secondary Outcome Measures
Name Time Method