Study the effects of one drug(dexmedetomidine) via two different routes i.e., through the vein or into the spinal fluid along with a common drug(bupivacaine) injected into the spinal fluid to eliminate the feeling of pain in patients undergoing lower limb and lower abdomen surgery.
Phase 4
Completed
- Registration Number
- CTRI/2018/08/015301
- Lead Sponsor
- dranshu
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
1.Patients undergoing elective infraumbilical or lower limb surgery under spinal anaesthesia 2.Belonging to American Society of Anaesthesiologists Physical Status 1 or 2
Exclusion Criteria
1.coagulopathy
2.hypovolaemia
3.BMI >35kg/m2
4.spinal abnormality
5.chronic use of sedatives or antidepressants
6.history of regular alcohol consumption
local infection over lumbar spine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Onset of sensory and motor blockade <br/ ><br>2.Time to achieve maximum sensory level <br/ ><br>3.Time for 2-segment regression <br/ ><br>4.sensory and motor recoveryTimepoint: 1.Sensory and motor blockade was checked every 2 minutes until the desired level was obtained. Every 5 minutes thereafter till the end of 1 hour, and every 15 minutes thereafter till end of procedure. <br/ ><br>3.Sedation score was recorded every 15 minutes throughout the first 3 hours. <br/ ><br>4.Blood pressure and heart rate was recorded every 5 minutes for the first hour and every 15 minutes thereafter till complete sensory and motor recovery
- Secondary Outcome Measures
Name Time Method 1.Sedation score( Ramsay sedation score) <br/ ><br>2.Hemodynamic parameters(Blood Pressure 25% decrease was treated, heart rate 50bpm was treated as per the discretion of concerned anaesthesologist, Respiratory rare 8/min or spO2 95% was taken as significant. <br/ ><br>Timepoint: 2