A Study To Investigate The Effect Of Inhaled Fluticasone Propionate On The Bronchial Responsiveness To Leukotriene D4 In Asthmatics Patients

Phase 4

Completed

• Conditions: Asthma; Mild Asthma

• Registration Number: NCT00453778
• Lead Sponsor: GlaxoSmithKline

Brief Summary

Investigate if asthmatics treated with FLIXOTIDE (FP) 500 mcg BID during 14 days get reduced bronchial reactivity after inhalation of Leukotriene D4. Two 14 days treatment periods where patients received FP 500 MCG BID and placebo. Washout at least 21 days between treatments. Bronchial challenge with methacholine and Leukotriene D4 were performed before the start of each treatment period and on treatment days 13 and 14 respectively.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-11
• Primary Completion: 2004-05
• Study Completion: 2004-05
• Study First Submitted: 2007-03-27
• Study First Submitted QC: 2007-03-28
• Study First Posted: 2007-03-29
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-11
• Last Update Posted: 2013-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
LTD4 PC20

Secondary Outcome Measures

Name	Time	Method
Shift in methacholine PD20