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Clinical Trials/CTRI/2025/09/095415
CTRI/2025/09/095415
Not yet recruiting
Not Applicable

Effect of Yoga on Pain, Psychological Symptoms and Prostaglandin Levels in Primary Dysmenorrhea: A Randomized Controlled Trial

Reena Singh1 site in 1 country154 target enrollmentStarted: October 10, 2025Last updated:

Overview

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Reena Singh
Enrollment
154
Locations
1
Primary Endpoint
COX menstrual symptom scale

Overview

Brief Summary

This randomized waitlist-controlled trial investigates the impact of a validated yoga practices on menstrual pain, psychological outcomes, and prostaglandin E2 levels in female college students with primary dysmenorrhea. The study evaluates multiple outcomes, including menstrual pain (Visual Analogue Scale), menstrual symptom severity (Cox Menstrual Symptom Scale), prostaglandin levels (measured by ELISA), Stress (Perceived Stress Scale), emotion regulation (Emotion Regulation Questionnaire), menstrual sensitivity (Menstrual Sensitivity Index), symptom interference, and daily symptom patterns.

Participants in the intervention group will undergo a validated six-month yoga program delivered in a hybrid format. The waitlisted control group will continue with their usual lifestyle and will be offered yoga practices after intervention completion.

The study hypothesizes that the yoga will significantly reduce menstrual pain, improve stress management and emotional regulation, and lower prostaglandin levels, thereby enhancing menstrual and psychological health in females with primary dysmenorrhea.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
Outcome Assessor Blinded

Eligibility Criteria

Ages
18.00 Year(s) to 28.00 Year(s) (—)
Sex
Female

Inclusion Criteria

  • Females aged 18 to 28 years.
  • Females complaining of painful menstruation at least two consecutive cycles.
  • Females with Visual Analogue Score (VAS) 5 or higher.
  • Females having a regular menstrual cycle (28± 7 days); regular menses for at least six previous cycles.
  • Females who consented to participate in the study and are willing to be randomized.
  • They should be university/college students and commit to an initial 3 months of regular practice of yoga.
  • No prior regular yoga practice (less than once a week in the past 6 months).

Exclusion Criteria

  • Females with irregular menstrual cycle.
  • Receiving any alternative treatments.
  • Reported history of mental illnesses or substance abuse (based on their self-report).
  • Females of pathological pelvic conditions and Polycystic Ovarian Disease (PCOD) through their medical history.
  • Married women and those who intent to get married within the proposed intervention duration.

Outcomes

Primary Outcomes

COX menstrual symptom scale

Time Frame: Baseline and Post(24 Weeks)

(CMSS)

Time Frame: Baseline and Post(24 Weeks)

Secondary Outcomes

  • 1.Prostaglandin PGE2 by ELISA(2.Pain severity assessment by VAS)

Investigators

Sponsor
Reena Singh
Sponsor Class
Other [individual]
Responsible Party
Principal Investigator
Principal Investigator

Reena Singh

S-VYASA Deemed to be University

Study Sites (1)

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