Does Tranexamic Acid reduce transfusion rate in Total Hip Replacements?

Phase 4

Completed

• Conditions: Osteoarthritis; Avascular necrosis of the femoral head; Musculoskeletal - Osteoarthritis; Musculoskeletal - Other muscular and skeletal disorders; Surgery - Other surgery

• Registration Number: ACTRN12610001065088
• Lead Sponsor: Dr James Blackett

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-12-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Primary total hip replacement
Diagnosis of osteoarthritis or avascular necrosis

Exclusion Criteria

Contraindications for tranexamic acid
Bleeding disorder
Use of Warfarin or Clexane or clopidogrel
History of thromboembolic disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in total units transfused over selected number of patients. From current average of 0.3units per patient to 0.15 units per patient. Data to be recorded from patient notes[One Week post surgery]

Secondary Outcome Measures

Name	Time	Method
Reduction in blood loss post-operatively. Using amount of blood drained from subfascial drain left in place for 24 hours. Data to be taken from patient notes[First 24 hours post surgery];Reduction in post-operative Haemoglobin drop. Haemoglobin to be check pre-op and Day 1 post-operatively and Day 5 post-operatively. Looking for differenced in expected post-operative drop[Five Days post surgery]