Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST

Not Applicable

Completed

• Conditions: Erythermalgia
• Interventions: Other: impedance measurement and pain evaluation

• Registration Number: NCT03044340
• Lead Sponsor: Fondation Hôpital Saint-Joseph

Brief Summary

Erythromelalgy (EM) is a vascular syndrome very rare affecting the feet. This disease evolve by crisis when the feet extremities become red hot and painful. There are several types of EM but this study concern the adult primitive form. For a long time, the physiopathology was not described but now we know that there is a vascular form, with microcirculatory dysfunction and a neurologic form with small fibers neuropathy. The diagnostic of neurologic form is based on clinical evaluation (DN4 questionnaire, UENS scale...) and an electromyography. Thermotest, a medical device which measure the thermic sensitivity is used to quantify neuropathy. More recently Sudoscan, a device measuring cutaneous impedance to chloride ions detect small nervous fiber in diabetic patients with good correlation with Thermotest.

The purpose of this study is to analyze the vascular side and the neurologic side on patients consulting for Erythromelalgy.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-12
• Study First Submitted: 2017-01-31
• Study First Submitted QC: 2017-02-02
• Study First Posted: 2017-02-07
• Primary Completion: 2018-01-18
• Status Verified: 2019-04
• Study Completion: 2019-04-17
• Last Update Submitted: 2019-04-24
• Last Update Posted: 2019-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• Pain with burn feeling at hands and feet extremities
• Crisis activated by the heat
• Age > 18 years old

Exclusion Criteria

• Patients who had burn in extremities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
erythermalgia patient	impedance measurement and pain evaluation	patient will be measured chlorine ions impedance with the SUDOSCAN and evaluation on pain du to temperature with the THERMOTEST

Primary Outcome Measures

Name	Time	Method
Assessment of Chlorine ion production change	Day1	patient will be measured the impedance of chlorinates ions by Sudoscan
Assessment of Temperature changing sensitivity	Day1	Patients will be measured their sensitivity to temperature changing using the Thermotest

Trial Locations

Locations (1)

Groupe Hospitalier Paris Saint Joseph; 🇫🇷 Paris, Ile-de-France, France