COMPARATIVE STUDY BETWEEN LUNG PROTECTIVE AND CONVENTIONAL VENTILATION UNDERGOING CRANIOTOMY UNDER GENERAL ANAESTHESIA TO STUDY POSTOPERATIVE PULMONARY COMPLICATIONS.

Not Applicable

• Conditions: Health Condition 1: G89-G99- Other disorders of the nervous systemHealth Condition 2: G978- Other intraoperative and postprocedural complications and disorders of nervous system

• Registration Number: CTRI/2021/02/031326
• Lead Sponsor: VARDHAMAN AND MAHAVIR MEDICAL COLLEGE AND SAFDARJUNG HOSPITA

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Adults with American Society of Anaesthesiologist (ASA) physical status 1 and 2 undergoing elective neurosurgery with craniotomy in supine position, age between 18yrs-70yrs , Glasgow coma scale(GCS) >=8, Duration of surgery > 2 hours

Exclusion Criteria

Patients with history of chronic lung disease and pulmonary infection, past history of

pulmonary surgery or received mechanical ventilation in past 2 weeks, heart disease, pregnant women, sepsis or septic shock, Body mass index (BMI) >35 kg/m2, patients requiring postoperative ventilation for >48hrs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the incidence of postoperative pulmonary complications with the use of lung protective and conventional ventilation in adult patients undergoing craniotomy under general anaesthesiaTimepoint: 24 HOURS AND TILL THE PATIENT IS SYMPTOMATIC FOR 1 WEEK OR DISCHARGE OR DEATH WHICHEVER IS EARLIER

Secondary Outcome Measures

Name	Time	Method
1) To compare intraoperative and postoperative arterial blood gas analysis, PaO2/FiO2 <br/ ><br>2) To compare Intraoperative ventilator parameters( dynamic lung compliance, respiratory index, oxygen index, driving pressure) <br/ ><br>3) To compare brain relaxation in the two groups. <br/ ><br>4) To compare intraoperative and postoperative hemodynamic parameters.Timepoint: At baseline and every 5 minutes interval till half an hour after intubation followed by <br/ ><br>30 min interval till the end of surgery and also at the below time intervals: <br/ ><br>T1- before changing the ventilator setting and after hemodynamic stabilization after intubation <br/ ><br>T2- 1h after changing the ventilator strategy <br/ ><br>T3- at the end of surgery <br/ ><br>T4- immediately after extubation