Comparison of 3 Protective regimens for preventing contrast-induced nephropathy in high risk patients

Not Applicable

• Conditions: Contrast-induced nephropathy.; Nephropathy induced by heavy metals

• Registration Number: IRCT201202062560N6
• Lead Sponsor: Qom University of Medical Sciences and Health Services

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 147

Inclusion Criteria

Patients, who have at least one of the following risk factors: 1) Age>65 years, 2) Diabetes mellitus, 3) Heart failure (25%>ejection fraction>40%), 4) Renal insufficiency (creatinine³1.5mg/dl), 5) Control hypertension (systolic and diastolic blood pressure <160 mm Hg and < 100 mm Hg, respectively), 6) Recent use of NSAID’S, ACE inhibitor and amino glycosides drugs. Exclusion criteria : 1) Pregnancy & lactation, 2) Allergy to radiographic contras,t 3) Have of cardogenic shock, pulmonary edema, multiple myeloma, pulmonary ventilation and emergency catheterization 4) Serum creatinine levels< 4 mg/dL and preexisting dialysis 5) Exposure to contrast medium within the preceding 48 hours of the study, 6) Receive of diuretics, N-acetylcystein, sodium bicarbonate, theophylline, dopamine, mannitol, fenoldopam, metformin and NSAID’S during the study period. 7) Need for continuous hydration therapy (e.g., sepsis), 8) Uncontrolled hypertension (systolic and diastolic blood pressure >160 mm Hg and >100 mm Hg, respectively)

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decrease of contrast-Induced nephropathy. Timepoint: Serum creatinine and blood urea nitrogen (BUN) levels will be measured in the morning on the first day before coronary angiography (day 1) and in the morning on second day after the procedure. PH urine level will be measured in the morning on the day before and after coronary angiography. Method of measurement: Serum creatinine, blood urea nitrogen (BUN) and PH urine levels will be measured, and creatinine clearance will be calculated according to the Cockcroft-Gault equation.