Comparison of 3 commonly used anaesthetic drugs - Ketamine, Midazolam and Pethidine, given in 3 different combinations, administered via intravenous route to prevent post spinal shivering
Phase 2
- Conditions
- Health Condition 1: null- shivering post neuraxial anaesthesia
- Registration Number
- CTRI/2018/01/011430
- Lead Sponsor
- Kasturba Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA physical status 1 and 2 patients who are scheduled for elective lower abdominal and lower limb surgeries under spinal anaesthesia.
Exclusion Criteria
Patient refusal,
Severe systemic disorders like diabetes mellitus, hypertension, cardiopulmonary disease, etc.
Body mass index of >=30 kg/m2,
Known history of alcohol or substance abuse.
Renal insufficiency,
Peptic ulcer disease,
Thyroid disease,
Psychiatric disorder,
Pregnancy,
Acute infections e.g. upper respiratory tract infection or urinary tract infection etc., and fever due to any other cause.
Allergy to any of the study drugs and all known contraindications to spinal anaesthesia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Incidence and grading of intraoperative shivering. <br/ ><br>2. Core body temperature and body surface temperatureTimepoint: After spinal anaesthesia, every 10 minutes for 60 minutes
- Secondary Outcome Measures
Name Time Method 1.Measurement of vital signs- HR, Blood pressure, Mean arterial pressure, SPO2. <br/ ><br>2. Adverse effects- hypotension, hallucination, nausea and vomitingTimepoint: Every 5 minutes for 30 minutes