Assessing the role of serum cortisol and Aβ42 in the prediction of early onset Alzheimers Disease in patients with Generalized Anxiety Disorders and Stage III/IV periodontitis.
- Conditions
- Health Condition 1: K053- Chronic periodontitis
- Registration Number
- CTRI/2021/05/033422
- Lead Sponsor
- JEYVARSHINI K
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 56
Inclusion criteria for healthy individuals:
According to the new classification scheme (Kornman and Tonetti et al, 2018).
Pristine periodontal health:
No bleeding on probing.
Normal gingival sulcus depth.
Normal bone heights.
Controlled modifying factors.
Controlled predisposing factors.
2.Clinical periodontal health (intact periodontium):
No or minimal bleeding on probing.
Normal gingival sulcus depth.
Normal bone heights.
Controlled modifying factors.
Controlled predisposing factors.
Inclusion criteria for Stage III/IV Periodontitis:
According to the new classification scheme (Kornman and Tonetti et al, 2018).
1.Stage III:
Interdental clinical attachment loss at site of greatest loss >= 5mm.
Radiographic bone loss extending to middle or apical third of root
Tooth loss due to periodontitis <= 4 teeth.
Probing depth >= 6mm.
Extent: Greater than 30% of teeth involved (Generalized)
2.Stage IV:
Interdental clinical attachment loss at site of greatest loss >= 5mm.
Radiographic bone loss extending to middle or apical third of root
Tooth loss due to periodontitis >= 5 teeth.
Extent: Greater than 30% of teeth involved (Generalized)
Inclusion criteria for Generalized Anxiety Disorders
Ability to provide details for DASS21 questionnaire
DASS21 score demonstrating moderate and severe depression or anxiety or stress
Patients with no other medical complications.
For depression: moderate score 14-20 and severe score 21-27
For anxiety: moderate score 10-14 and severe score 15-19
For stress: moderate score 19-25 and severe score 26-33
History of periodontal treatment within the previous 6 months.
Smoking and alcohol consumption
Pregnant and lactating women.
History of antibiotic therapy in the past 3 months.
Patients with any other systemic inflammatory conditions.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the level of Aβ42 in the serum of patients with and without Generalized Stage III/IV Periodontitis and generalized anxiety disorders. <br/ ><br> <br/ ><br> <br/ ><br> To assess the levels of cortisol in serum of patients with and without Generalized Stage III/IV Periodontitis and generalized anxiety disorders. <br/ ><br>Timepoint: At baseline
- Secondary Outcome Measures
Name Time Method To correlate the serum levels of Aβ42 ,cortisol and clinical parameters of periodontal inflammation with the risk of developing early onset Alzheimers Disease.Timepoint: At baseline