Altering the cough response after stroke

Not Applicable

• Conditions: Dysphagia; Dystussia; Stroke - Ischaemic; Stroke - Haemorrhagic; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12623000422628
• Lead Sponsor: niversity of Canterbury

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-28
• Last Update Posted: 15 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Participants will be/have:
- Over the age of 18 years
- Able to give informed consent
- A diagnosed stroke
- Intact volitional cough (indicating that motor innervation of the cough response is intact)
- An absent cough response to a 0.4 mol/L concentration of citric acid (completed in Session 1 after giving consent)
- Spirometry results that do not demonstrate an obstructive pattern (a lung function ratio that is below the lower limit of the normal range – (completed in Session 1 after giving consent)

Exclusion Criteria

Participants will not be/have:
- A communication or cognitive impairment
- A diagnosed progressive neurological disease (eg Multiple Sclerosis, Motor Neurone Disease, Parkinson’s Disease)
- A history of cancer of the head, neck or lungs
- Any history of respiratory conditions including COPD and asthma (or any prior use of an inhaler)
- A current smoker / vaper or have ceased smoking within last 6 months
- Poorly controlled reflux
- Currently taking or have taken any opioid pain medications in the last 6 months
- Currently taking or have taken any ACE inhibitor medications in the last 3 months
- Currently taking or have taken any antipsychotic medications in the last 6 months
- A current or recent respiratory tract infection in the last 2 weeks including displaying symptoms of a cold, flu or COVID-19
- A myocardial infarction in the last 4 weeks
- Eye surgery in the last 2 weeks
- Previous bad reaction to any inhaled therapies in the past (e.g. allergic type reaction)

Study & Design

• Study Type: Interventional
• Study Design: Not specified