Maternal Grandmothers in the Born in Guangzhou Cohort Study

Recruiting

• Conditions: Hereditary Transmission; Immune Development; Childhood Obesity; Host and Microbiome; Neurodevelopment

• Registration Number: NCT03633162
• Lead Sponsor: Guangzhou Women and Children's Medical Center

Brief Summary

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Detailed Description

It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Study Timeline

• Study Start: 2018-05-21
• Study First Submitted: 2018-07-23
• Study First Submitted QC: 2018-08-13
• Study First Posted: 2018-08-16
• Status Verified: 2024-09
• Last Update Submitted: 2024-09-27
• Last Update Posted: 2024-09-30
• Primary Completion: 2025-12-31
• Study Completion: 2038-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 5000

Inclusion Criteria

1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
2. Baseline information of maternal grandmother's daughter during pregnancy available

Exclusion Criteria

1. Significant cardiovascular abnormalities
2. Intelligent obstacle, intellectual disabilities or gawkish condition

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring	From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth	Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers

Secondary Outcome Measures

Name	Time	Method
Changes of body composition of grandchildren	At age of 3 years,6 years, 12years and 18years	Body composition is assessed using Dual Energy X-Ray Absorptiometry
Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life	At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren	Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc.
The prevalence of Allergic rhinitis of grandchildren	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren	Assessed by self-reported time of onset and electronic medical record
The incidence of asthma of grandchildren	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren	Assessed by self-reported time of onset and electronic medical record
The prevalence of Food allergy of children and grandchildren	At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren	Assessed by self-reported time of onset and electronic medical record
The prevalence of eczema of grandchildren	At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren	Assessed by self-reported time of onset and electronic medical record
Changes of bone density of grandchildren	At age of 3 years,6 years, 12years and 18years	Bone density is assessed using Dual Energy X-Ray Absorptiometry

Trial Locations

Locations (1)

Guangzhou Women and Children's Medical Center; 🇨🇳 Guangzhou, Guangdong, China