The Born in Guangzhou Cohort Study (BIGCS)

Recruiting

• Conditions: Immune Development; Childhood Obesity; Intrauterine Hyperglycemia; Pregnancy Outcomes; Neurodevelopment; Host and Microbiome
• Interventions: Other: No intervention

• Registration Number: NCT02526901
• Lead Sponsor: Guangzhou Women and Children's Medical Center

Brief Summary

The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.

Detailed Description

Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.

Study Timeline

• Study Start: 2012-02-01
• Study First Submitted: 2015-08-13
• Study First Submitted QC: 2015-08-16
• Study First Posted: 2015-08-18
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-22
• Last Update Posted: 2024-02-26
• Primary Completion: 2025-12-31
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30000

Inclusion Criteria

• Pregnant women with <20 weeks of gestation
• Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
• Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No treatment	No intervention	-

Primary Outcome Measures

Name	Time	Method
Number of participant with pregnancy outcomes	At delivery	Including abortion, stillbirth, live birth, preterm birth, low birth weight and birth defects

Secondary Outcome Measures

Name	Time	Method
Height changes during early childhood	At birth, age of 6 weeks, 6 months, 1 year and 3 years	Height changes from birth, 6 weeks, 6 months, 1 year to 3 years
Neurodevelopment during early childhood	At age of 3 years	Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules and Ages and Stages Questionnaire
Weight changes during early childhood	At birth, age of 6 weeks, 6 months, 1 year and 3 years	Weight changes from birth, 6 weeks, 6 months, 1 year to 3 years
Changes of body composition during early childhood	At birth, age of 6 weeks, 6 months, 1 year and 3 years	Changes of body composition from birth, 6 weeks, 6 months, 1 year to 3 years. Body composition is assessed using Dual Energy X-Ray Absorptiometry

Trial Locations

Locations (1)

Guangzhou Women and Children's Medical Center; 🇨🇳 Guangzhou, Guangdong, China