Birth Cohort Study of China Medical University
- Conditions
- Scarred UterusOverweight and ObesityTwin; Complicating PregnancyAdvanced Maternal Age Pregnancy
- Registration Number
- NCT03561766
- Lead Sponsor
- Shengjing Hospital
- Brief Summary
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental factors, family and lifestyle, clinical experimental outcomes and imaging results of pregnant women and children from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the children and their parents.
- Detailed Description
Early life phase (fetal and infant) is a critical period for the development of health and disease in a person's life. Many adult chronic diseases, such as diabetes, cardiovascular and cerebrovascular diseases, all come from the exposure of negative environmental and behavioral factors during this period. By collecting the lifestyle data and clinical data of pregnant women at different periods, the appropriate indicators are anticipated to be selected to predict and evaluate the outcome of pregnancy and the health of the mothers and children in the long term. The status of overweight and obesity of children in Shenyang and its surrounding areas are anticipated to be analyzed by descriptive and etiological analysis through collecting the lifestyle data and clinical data of different periods of pregnant women and the lifestyle data of different developmental stages of children.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 1000
- Pregnant women, <13 gestational weeks
- Permanent residents or families intended to remain in Shenyang and surrounding areas
- Pregnant women who are planned to be examined and delivered in Shengjing Hospital.
- Pregnant women who refuse to take part in the study
- Pregnant women have diseases that might affect the results of researches, including neuropsychiatric disorders.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age At every week from the thirteenth week of gestational age to delivery of babies Including head circumference, abdominal circumference, biparietal diameter, femur length of singleton and twin pregnancy
Weight in kilogram of neonate At birth of neonate Including singleton and twin pregnancy measured by nurses
Gene expression of husbands of pregnancy women At 13 weeks of gestational age DNA methylation, histone acetylation etc. assessed by analyses of blood
Result of Non-invasive Prenatal Testing From 12 to 22 weeks of gestational age including singleton and twin pregnancy
Change of gene expression of pregnancy women At 13, 26 and 34 weeks of gestational age DNA methylation, histone acetylation etc. assessed by analyses of blood
- Secondary Outcome Measures
Name Time Method Change of intestinal flora during early childhood Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years Assessed by analyses of stool samples
Weight in kilogram changes during childhood Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years Measured by nurses in clinic
Height in centimeter changes during childhood Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years Measured by nurses in clinic
Change of gene expression during childhood Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years DNA methylation, histone acetylation etc. assessed by analyses of blood
Trial Locations
- Locations (1)
Shengjing Hospital
🇨🇳Shenyang, Liaoning, China