Chinese Multi-provincial Cohort Study-Beijing Project

• Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; Smell Disorder; Aging Problems; Sleep

• Registration Number: NCT04253054
• Lead Sponsor: Beijing Institute of Heart, Lung and Blood Vessel Diseases

Brief Summary

The Chinese Multi-provincial Cohort Study (CMCS)-Beijing project is a sub-study in CMCS participants from Beijing, which intended to investigate the progression and determinants of atherosclerosis and aging related health problems through repeat examinations. Exam 0 to Exam 3 have been conducted during 1992 to 2012. Exam 4 is scheduled in 2020.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-01-22
• Study First Submitted QC: 2020-01-31
• Study First Posted: 2020-02-05
• Study Start: 2020-09-07
• Status Verified: 2020-12
• Last Update Submitted: 2020-12-02
• Last Update Posted: 2020-12-04
• Primary Completion: 2021-03
• Study Completion: 2021-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Participants from CMCS-Beijing
• sign the informed consent

Exclusion Criteria

• participanting in clinical trials

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All fatal and nonfatal acute coronary and stroke events	From date of enrollment until the date of first documented event or date of cardiovascular death, whichever came first, assessed at least 5 years	Acute coronary heart disease events included acute myocardial infarction, sudden death, and other coronary deaths. Acute stroke events included subarachnoid hemorrhage, intracerebral hemorrhage, or cerebral infarction.

Secondary Outcome Measures

Name	Time	Method
Cognitive dysfunction	From date of enrollment until date of first documented event, assessed at least 5 years	Cognitive dysfunction
Valvular disease	From date of enrollment until the date of first documented event or date of valvular disease death, whichever came first, assessed at least 5 years	Valvular disease
New-onset of stroke	From date of enrollment until the date of first documented event or date of stroke death, whichever came first, assessed at least 5 years	Acute stroke events included subarachnoid hemorrhage, intracerebral hemorrhage, or cerebral infarction.
Total death	From date of enrollment until date of death from all cause, assessed at least 5 years	All cause death
Olfactory Disorders	From date of enrollment until date of first documented event, assessed at least 5 years	Olfactory Disorders
New-onset of coronary events	From date of enrollment until the date of first documented event or date of CHD death, whichever came first, assessed at least 5 years	Acute coronary heart disease events included acute myocardial infarction, sudden death, and other coronary deaths.

Trial Locations

Locations (3)

Beijing Sijiqing Hospital, Beijing; 🇨🇳 Beijing, China

Peking University Shougang Hospital; 🇨🇳 Beijing, China

Peking University Hospital, Beijing; 🇨🇳 Beijing, China