The China-Anhui Birth Cohort Study (C-ABCS)

Completed

• Conditions: Children Development; Other Pregnancy With Abortive Outcome; Environmental Exposures; Birth Defects

• Registration Number: NCT02391610
• Lead Sponsor: Fangbiao Tao

Brief Summary

The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development. The C-ABCS recruited pregnant women from six major cities of Anhui province, China, between November 2008 and October 2010. A range of data (including demographic, obstetric, occupational, nutritional and psychosocial factors) were collected by both interviews and laboratory tests. In each trimester, women's blood samples were drawn, and pregnancy complications were abstracted from physician's medical records. By the end of 2011, birth outcomes/birth defects were observed/identified by clinicians within 12 months after the delivery of 11 421 singleton live births of six cities and those outcomes among the remaining 2033 live births are still being observed. In addition, 4668 children from Ma'anshan city will be further followed up during the pre-school period till they reach adolescence to obtain the data on familial environmental exposures as well as children's physical, psychological, behavioural and sexual development. The interview data and information on laboratory examinations are available on request from archives in the Anhui Provincial Key Laboratory of Population Health \& Aristogenics.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-11
• Primary Completion: 2010-10
• Study Completion: 2015-01
• Status Verified: 2015-03
• Study First Submitted: 2015-03-12
• Study First Submitted QC: 2015-03-12
• Last Update Submitted: 2015-03-12
• Study First Posted: 2015-03-18
• Last Update Posted: 2015-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 16766

Inclusion Criteria

1. Having been lived in local city at least 6 months;
2. Establishing maternal card in the hospital for the first time;
3. Gestational week ≤ 16 weeks;
4. Willing to have antenatal checkups and childbirth in the hospital where they establish maternal cards.

Exclusion Criteria

1. Women who have abnormities in speaking and can not complete the survey by themselves;
2. Women with mental disorders;
3. Women who plan to leave local places.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pregnancy outcomes and birth defects	Up to 12 months of age	By clinical diagnosis, including abortion/premature birth/prolonged pregnancy/fetal death/stillbirth/live birth, Low birthweight/macrosomia/small for gestation age/large for gestation age, Structural birth defects and functional birth defects

Secondary Outcome Measures

Name	Time	Method
Family environmental exposure	At ages of 1.5-3 and 4.5-6 years	Eating patterns and parenting style.
Mental health problems	At ages of 1.5-3 & 4.5-6 years	Mental retardation, attention deficit hyperactivity, disorder, autism spectrum disorders.
Sexual development indicators	At ages of 9-15 years for boys, and 8-14 years for girls	Secondary sexual characters, Sexual hormones.
Psychological and behavioural development	At ages of 1.5-3 and 4.5-6 years	cognition, behaviour and temperament
Children's physical development	At ages of 1.5-3 and 4.5-6 years	Including body height/length, body weight, blood pressure, blood lipoid