Twins Born in Guangzhou
- Conditions
- Host and MicrobiomeNeurodevelopmentChildhood ObesityTwin DiseasesImmune Development
- Interventions
- Other: No intervention
- Registration Number
- NCT03331133
- Lead Sponsor
- Guangzhou Women and Children's Medical Center
- Brief Summary
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
- Detailed Description
Twins share the same intrauterine environment and the early family environment. When conducting research of chronic disease etiology, twins cohort can be a good control of bias from age, gender, genetic and early environment. Twin-based designs provide an estimate of the relative contribution of genetic and non-genetic factors to a specific phenotype. Twins study has an advantage of calculating heritability of traits. Since heritability of traits is various from different populations. It is important to establish database to calculate the heritability of traits associated with chronic major diseases in Chinese population. Twins cohort is rare in China at present. Therefore, extensive information including physical characteristics, mental health, and behaviors is collected from both twins and their parents. Longitudinal follow-up and surveillance of common diseases are also to be conducted. The 2-BIG aims to explore epigenetic markers and genes related to health status, as well as gene-environment interactions on diseases, both in intrauterine and childhood stages, especially in Chinese population.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1000
- Live twins delivered in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years
- Baseline information during pregnancy available
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Dizygotic Twins No intervention Twins develop from two different zygote with no intervention Identical Twins No intervention Twins develop from one zygote with no intervention
- Primary Outcome Measures
Name Time Method Change of gene expression during childhood Age at 1 year , 6 years, 12years and 18years DNA methylation, histone acetylation etc. assessed by analyses of blood samples
Intelligence quotient At age of 6 years old Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.
Neurodevelopment at early childhood At age of 1 year old Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
- Secondary Outcome Measures
Name Time Method Change of intestinal flora during early childhood Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years Assessed by analyses of stool samples
Changes of body composition and bone density during early childhood At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years Body composition and bone density are assessed using Dual Energy X-Ray Absorptiometry
Height in kilometer changes during childhood At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year Measured by nurses in clinic
Weight in kilogram changes during childhood At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year Measured by nurses in clinic
Trial Locations
- Locations (1)
Guangzhou Women and Children's Medical Center
🇨🇳Guangzhou, Guangdong, China