clinical trial of the effect of raw and cooked milk immunotherapy in children with milk allergy
- Conditions
- food allergy.Allergy, unspecified
- Registration Number
- IRCT20170426033658N2
- Lead Sponsor
- Vice chancellor for Research of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25
patients two years and older
Presentation of skin symptoms such as urticaria, erythema and angioedema
gastrointestinal symptoms such as severe vomiting, abdominal pain and diarrhea
respiratory symptoms such as rhinitis and bronchospasm
Presentation of the symptoms up to two hours after exposure
these symptoms should be present at least in last six months
positive skin prick test for cow's milk or measurement of sIgE for cow's milk
positive challenge test with cow's milk
cellular immune response that is not mediated by IgE
malignancy or severe immunodeficiency disorders
using beta blockers
uncontrolled severe persistent asthma
Cardiovascular disease that epinephrine administration is contraindicated in them
Taking immunosuppressive drugs
previously diagnosed Eosinophilic Gastrointestinal Disorder in response to milk
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Regulatory T cell. Timepoint: Before intervention, after intervention. Method of measurement: Flow cytometry.;Specific IGE for milk. Timepoint: Before intervention, after intervention. Method of measurement: RIDA.;Milk Desensitization. Timepoint: Before intervention, after intervention. Method of measurement: Clinical.
- Secondary Outcome Measures
Name Time Method Symptoms,anaphylaxis,desensitization. Timepoint: Immediately after intervention. Method of measurement: physical examination.