The effect of melatonin supplementation on migraine

Not Applicable

• Conditions: Condition 1: Migraine. Condition 2: Migraine.; Migraine; G43.0; G43.1

• Registration Number: IRCT20121216011763N40
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 December 2019

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 88

Inclusion Criteria

Women from the age of 18 to menopause
Diagnosis of migraine by a neurologist
Willing to work with the project

Exclusion Criteria

People with a history of overdose of analgesics according to IHS criteria for antidepressant abuse
Pregnancy or breast-feeding
History of significant complications or recent use of melatonin supplements
Severe depression in the past year

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Migraine symptoms (severity, frequency, duration of migraine). Timepoint: Week 0 and Week 8. Method of measurement: Questionnaire.;Serum levels of calcitonin-associated peptide (CGRP). Timepoint: Week 0 and Week 8. Method of measurement: Laboratory analysis (blood test).

Secondary Outcome Measures

Name	Time	Method
Depression, stress, anxiety. Timepoint: week 0 and week 8. Method of measurement: DASS-21questionnaire.;Quality of Life in Migraine Patients. Timepoint: week 0 and week 8. Method of measurement: Migraine –Specific Quality of Life(MSQ)questionnaire.