The clinical trial on the effect of supplementation of tablet melatonin in generalised periodontitis
Phase 1
- Conditions
- Health Condition 1: D50-D89- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Registration Number
- CTRI/2020/04/024535
- Lead Sponsor
- self funded
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Healthy adult patients between 25-70 years.
2.Individuals with mild to severe periodontitis
Exclusion Criteria
1.smoking >20 cigarettes/day
2.uncontrolled diabetes
3.immunosuppression (pathological or drug-induced)
4.current therapy with antiresorptive drugs (bisphosphonates)
5.pregnancy and breastfeeding
6.patients in need of antibiotic therapy or treatment with antibiotic in the previous month
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Following clinical parameters will be recorded at baseline for healthy group and periodontitis group:Plaque index (Silness and Loe 1967),Gingival index (GI),(Loe and Silness 1963),Probing depth,Clinical Attachment level and Serum IL-8 level. <br/ ><br>Timepoint: BASELINE
- Secondary Outcome Measures
Name Time Method Following clinical parameters will be recorded after 20 days only for experimental group:Plaque index (Silness and Loe 1967),Gingival index (GI),(Loe and Silness 1963),Probing depth,Clinical Attachment level and Serum IL-8 level <br/ ><br>Timepoint: 20 days