Investigating the effect of melatonin supplementation in obesity

Not Applicable

Conditions: Overweight and Obesity.
Obesity, unspecified
E66.9

Registration Number: IRCT20080904001197N22

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 46

Inclusion Criteria

Apparently healthy women volunteers
Literate
19-49 years
BMI=25-34.9 kg/m2
Having high hedonic eating intensity
Unwillingness to diet
Desire to use drugs or supplements to lose weight

Exclusion Criteria

Postmenopausal, pregnant or lactating women
Recent weight loss or participation in weight loss programs
Suffering from binge eating
Current smokers
Recent history of taking supplements affecting appetite (in the last 3 months)
Women who, according to themselves, are suffering from substance abuse, alcohol addiction, certain diseases such as cancer, heart disease and diabetes
Women who, according to themselves, have hypothyroidism and use medicine for this purpose
Women who, according to themselves, use drugs that affect appetite, such as antidepressants, steroids, and contraceptives
Having night shifts
Having severe insomnia or thyroid disorders
Using drugs that interfere with melatonin (anti-hypertensive drugs, anticonvulsant drugs, beta blockers, anticoagulant drugs, sedatives, antidepressants, oral contraceptive pill, corticosteroids)
Melatonin supplementation intolerance during the study
Using less than 90% melatonin supplements or placebo

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma level of acyl ghrelin. Timepoint: Before starting and at the end of the study. Method of measurement: ELISA.

Secondary Outcome Measures

Name	Time	Method
Plasma level of 2-arachidonylglycerol. Timepoint: Before starting and at the end of the study. Method of measurement: ELISA.;Hedonic eating score. Timepoint: The first phase of the study and at the end of the study. Method of measurement: Power of food scale.;Total energy intake. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: 3-day food recall.;Energy intake from macronutrients. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: 3-day food recall.;Weight. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: Scale.