Diagnosis of asthmatic patients using impulse oscillometry; a simple alternative to spirometry.

Completed

• Conditions: asthma bronchiale; asthma; 10038716

• Registration Number: NL-OMON45914
• Lead Sponsor: Haaglanden Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Adult patients (18 years and older) who are redirected to a secondary health care institute with the presumed diagnosis of asthma who have given informed consent to be included in the study.

Exclusion Criteria

Minors below 18 years of age, incapacitated adults and subject who have not signed the informed consent form.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The change of the AX area of the impulse oscillometry after taking Ventolin in<br /><br>comparison with the diagnosis of the pulmonary phycicians. The change of the AX<br /><br>area will be used to create an ROC-curve and the best cut off value will be<br /><br>determined. For this cut off value the sensitivity, specificity, positive<br /><br>prediction value, negative prediction value, positive likelihood ratio,<br /><br>negative likelihood ratio and diagnostic odds ratio will be determined,<br /><br>including their 95% confidence intervalls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The change of the R5 and X5 of the impulse oscillometry after Ventolin in<br /><br>comparison with the diagnosis of the pulmonary phycicians. The change of the R5<br /><br>and X5 area will be used to create an ROC-curve and the best cut off value will<br /><br>be determined. For this cut off value the sensitivity, specificity, positive<br /><br>prediction value, negative prediction value, positive likelihood ratio,<br /><br>negative likelihood ratio and diagnostic odds ratio will be determined,<br /><br>including their 95% confidence intervalls.<br /><br><br /><br>The change of the FEV1 of spirometry after Ventolin in comparison with the<br /><br>diagnosis of the pulmonary phycicians. The Mcnemar test will be used to see if<br /><br>there is a significant difference between the diagnostic accuracy of the FEV1<br /><br>of spirometry in comparison with the AX area of the impulse oscillometry.<br /><br><br /><br>The correlation between the R5, R20 and AX with the FEV1 will be determined.</p><br>